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This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti;
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Receptor Tyrosine Kinases, Volume 147 in the Advances in Cancer Research series, provides invaluable information on the exciting and;
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of acquired resistance to tyrosine kinase inhibitor drugs therapy in colon-rectal cancer. The authors summarize host cell and viral protein kinases;
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Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including;
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), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR). 2. Cytoplasmic tyrosine kinases like the;
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called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important;
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protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases;
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, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti;
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targeting receptor tyrosine kinases in cancer, -Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the;
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in GPCR signaling and their relevancy to cancer biology Presents new indications for anti-cancer therapeutic programs Includes;
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Lipsick discusses Myb and oncogenesis. Biscardi and colleagues present their research on c-Src, receptor tyrosine kinases, and human cancer;
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, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors;
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The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common;
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inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to;
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have only just begun to uncover. Recent research findings indicate that individual receptor kinases fulfill important roles in growth and;
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Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli;
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This book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase;
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Topics in this issueinclude: Targeting IGF-1R; Tyrosine Kinase Inhibitors in Lung Cancer; Targeting mTOR; Targeting Hedgehog; Mitotic;
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Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical;
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Approaches to Understanding Breast Cancer, Volume 151, the latest volume in the Progress in Molecular Biology and Translational Science;
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to interrupt the tumor-host interaction are among the most promising new leads to emerge in cancer pharmacogenomics and oncogenomics;
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, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new;
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landscape of anti-EGFR based cancer treatments, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. It offers;
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Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with;
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Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation;
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updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative;
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third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics;
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