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for drug discovery scientists to generate effective and safe drugs for unmet medical needs. Featuring case studies and lessons learned from;
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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for;
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. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety;
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As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the;
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to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families;
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next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention;
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Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists;
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priming of cytotoxic T lymphocyte responses; current anti-cancer agents targeting apoptosis and authophagy and clues for future cancer drug;
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Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer;
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well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.;
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and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the;
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and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the;
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ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from;
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of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic;
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Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which;
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, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting;
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focus of the book discusses the fundamentals of human disease and drug discovery. Various in silico, in vitro, and in vivo approaches for drug;
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therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a;
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for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters;
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computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations;
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Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization;
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conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and;
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Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so;
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and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on;
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Drug discovery and development are expensive and time-consuming processes. Removing non-drug-like compounds from the drug discovery;
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both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development * Adds coverage;
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This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront;
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