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Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies

study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function;

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Antisense Drug Technology

. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions;

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Manual of Antisense Methodology

In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic;

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Gene Silencing by RNA Interference

by RNA Interference: Technology and Application is the first to present the entire spectrum of activity, design, production, and delivery;

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RNA Interference

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly;

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Gapmers

This volume presents a comprehensive collection of detailed state-of-the-art protocols for gapmer-mediated RNA knockdown from leaders;

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Applied Antisense Oligonucleotide Technology

Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use;

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RNA Technologies and Their Applications

of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA;

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RNA Interference

RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and;

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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this;

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Research Progress in Antisense Elements (Genetics)

the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For;

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Non-viral Gene Therapy

RNase P and group I introns through hammerhead RNA enzymes, antisense technology, and more recently, to RNAi and its derivatives. A useful;

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RNA Purification and Analysis

for the enrichment, separation and purification of these novel RNAs. Building up from general principles of RNA biochemistry and biophysics;

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Antisense Elements (Genetics) Research Focus

for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with antisense sequence and the;

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RNA Recognition

quality chapters authored by leaders in the field. This updated volume covers a variety of topics, including The Preparation of cooperative RNA;

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CRISPR Guide RNA Design

This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire;

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Delivery Strategies for Antisense Oligonucleotide Therapeutics

, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense;

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Gene Silencing

mediate siRNA and shRNA delivery into the brain, siRNA delivery strategies as a therapeutic tool in gene therapy, galectin-3 epigenetics and;

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Studies on Protein

The central role of RNA in many cellular processes has created a high interest in the specific tasks RNA molecules and protein: RNA;

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A Comprehensive Guide to Aptamers

This collection opens with a focus on recent advancements on the development of nucleic acid aptamers as alternative delivery systems for;

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Gene Transfer

a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches;

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Gene Transfer

a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches;

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Recombinant and In Vitro RNA Synthesis

The discovery of catalytic RNAs in the mid-1980s marked the beginning of a new era in RNA biology and an ever increasing appreciation;

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Recombinant Virus Vaccines

; Part II discusses negative sense single-stranded RNA viruses; Part III talks about positive sense single-stranded RNA viruses; and Part IV;

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Synthetic Messenger RNA and Cell Metabolism Modulation

-transcriptional modification. mRNA, as a transfection agent, has several advantages over DNA, as mRNA expression is not dependent on nuclear entry and;

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Structures of Large RNA Molecules and Their Complexes

. This volume covers research methods in RNA folding and dynamics, RNA-protein interactions and large RNPs. Continues the legacy of this;

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Computational Methods for Understanding Riboswitches

. This volume covers computational prediction RNA structure and dynamics, including such topics as computational modeling of RNA secondary and;

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